She had been privately battling breast cancer for the past two years.
Kelly Preston has died after a two-year battle with breast cancer. Her husband, actor John Travolta, confirmed the news of her passing on Instagram. She was 57 years old.
"It is with a very heavy heart that I inform you that my beautiful wife Kelly has lost her two-year battle with breast cancer," Travolta, 66, wrote. "She fought a courageous fight with the love and support of so many."
A family representative also confirmed Preston's passing exclusively to People.
"On the morning of July 12, 2020, Kelly Preston, adored wife and mother, passed away following a two-year battle with breast cancer," the family representative said.
"Choosing to keep her fight private, she had been undergoing medical treatment for some time, supported by her closest family and friends," the family rep added. "She was a bright, beautiful and loving soul who cared deeply about others and who brought life to everything she touched. Her family asks for your understanding of their need for privacy at this time."
In addition to her husband John Travolta, Preston is survived by her their children: daughter Ella, 20, and 9-year-old son Benjamin. Son Jett died at age 16 in January 2009.
Preston, who was born Kelly Kamalelehua Smith on October 13, 1962, in Honolulu, Hawaii, studied acting at the University of Southern California (USC) and launched her career in 1985 with her first major movie role in Mischief after several minor roles in television shows, including For Love and Honor.
Over the next few years, Preston starred in films such as SpaceCamp (1986), Twins (1988), Jerry Maguire (1996) and For Love of the Game (1999). Preston's final film role was in the 2018 film Gotti in which she played Victoria Gotti, the wife of Mafia boss John Gotti, who was portrayed on screen by Travolta. She also collaborated with her husband in Battlefield Earth (2000) and Old Dogs (2009).
Preston's other notable film appearances include What A Girl Wants (2003), The Cat In The Hat (2003), and Broken Bridges (2006).